Darlene Gandolfi

Professor, Chemistry


Brownson Hall, 134

Dr. Darlene D'Alliessi Gandolfi is a professor of chemistry at Manhattanville University.  After receiving her BA, summa cum laude from Manhattanville, Dr. Gandolfi went on to earn a MS and PhD in chemistry from Yale University. Before returning to Manhattanville as a full-time faculty member, she worked as a postdoctoral research associate at Princeton University. Dr. Gandolfi's research interests include chirality in organometallic complexes, asymmetric catalysis, and synthesis of chemotherapeutic drugs. She has collaborated with her students on research projects in food chemistry, environmental chemistry, and the chemistry of herbal remedies. Her research has been published in the Journal of the American Chemical Society, Organometallics, Retrovirology, and PLoS ONE. Research on which she has collaborated has been presented at professional conferences in Australia, Canada, South Africa, Turkey, and within the United States.

Introduction to Chemistry
Principles of Chemistry I
Principles of Chemistry I Lab
Principles of Chemistry II
Principles of Chemistry II Lab

Chemistry, PhD, Yale University
Chemistry, MS, Yale University
Chemistry, BA, Manhattanville University
“Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial”

PLoS ONE 2016, 11(5): e0154842. doi:10.1371/journal.pone.0154842 
Co-author, Article 
Link to Article

“Drug-Induced Reactivation of Apoptosis Abrogates HIV-1 Infection”

PLoS ONE 2013, 8(9): e74414. doi:10.1371/journal.pone.0074414 
Co-Author, Research Paper 
Link to Research Paper

US Patent Application 20120225093 

Abrogating HIV-1 Infection via Drug-Induced Reactivation of Apoptosis 

“Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A” 

Retrovirology 6: 90 (2009) 
Co-Author, Research Paper 
Link to Research Paper

World Intellectual Property Organization Patent #WO/2006/039697

Method of Improving Drugs with Anti-Retroviral and Anti-Cancer Activity 

“Planar Chirality in Tethered η6: η 1-(Phosphinophenylenearene-P) ruthenium(II) Complexes and Their Potential Use as Asymmetric Catalysts”

Organometallics 2003, 22, 13, 2749-2757 
Co-Author, Research Paper

“Tunable Stereoselective Hydrosilylation of PhC≡CH Catalyzed by Cp*Rh Complexes” 

Organometallics 2002, 21, 8, 1743-1746 
Co-Author, Research Paper

“An Application of Electronic Asymmetry to Highly Enantioselective Catalytic Diels-Alder Reactions”

Journal of the American Chemical Society 2001, 123, 11, 2525-2529 
Co-Author, Research Paper